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Minamata disease (organic mercury poisoning)

Neuroradiologic and electrophysiologic studies

First Department of Internal Medicine, Kumamoto University Medical School. Kumamoto, Japan.

We studied 10 patients with Minamata disease (organic mercury poisoning) who have been followed for over 20 years. CT revealed a bilateral, symmetric, low-density area in the visual cortex and diffuse atrophy of the cerebellar hemispheres and vermis, especially the inferior vermis. Computerized quantitative analysis of the tremor of these patients showed a peculiar frequency of 7.075 Hz on postural tremor and 7.501 Hz on action tremor. On studies of short-latency somatosensory evoked potential, all patients showed a lack of the N20 component, the potential of the somatic sensory area.

Address correspondence and reprint requests to Dr. Uchino, First Department of Internal Medicine, Kumamoto University Medical School, 1-1-1, Honjo, Kumamoto City, Japan.

Accepted for publication April 23, 1982.

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