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Glucose utilization of cerebral gliomas measured by [¹⁸F] fluorodeoxyglucose and positron emission tomography

Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.

Positron emission tomography was used to measure local cerebral glucose utilization by the 2-[¹⁸F]fluoro-2-deoxy-D-glucose technique in 23 patients with cerebral gliomas. All 10 high-grade (III and IV) astrocytomas demonstrated a region of high activity with a glucose consumption of 7.4 ± 3.5 (SD) mg/100 gm per minute. The 13 low-grade (I and II) gliomas had a glucose metabolic rate of 4.0 ± 1.8 mg/100 gm per minute, with no distinctly visible hot spot. Thus, we found a correlation between rate of glycolysis and malignancy in primary cerebral tumors. Cerebral cortical glucose utilization was often depressed in areas adjacent to or neurally connected to the tumor site, and there was focal irregular delta wave EEG activity in these areas.

Address correspondence and reprint requests to Dr. Di Chiro, Neuroradiology and Computed Tomography Section, Building 10, Clinical Center, National Institutes of Health, Bethesda, MD 20205.

Accepted for publication May 13, 1982.

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