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Exacerbation of Charcot-Marie-Tooth disease in pregnancy

Division of Neurology, Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.

A severe exacerbation of subclinical Charcot-Marie-Tooth disease commenced in the third trimester of an otherwise normal pregnancy. Following cesarean section there was immediate improvement and twelve weeks later the patient was asymptomatic. It is concluded that Charcot-Marie-Tooth disease, like other forms of chronic demyelinating neuropathy, may be rarely exacerbated in pregnancy. Pathogenetic mechanisms leading to exacerbation of neuropathy in pregnancy may be related to nerve edema.

Address correspondence and reprint requests to Dr. Pollock, Department of Medicine, University of Otago Medical School, P.O. Box 913, Dunedin, New Zealand.

This study was aided by a grant from the Medical Research Council of New Zealand.

Accepted for publication March 16, 1982.