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Narcolepsy and idiopathic hypersomnia

Biogenic amines and related compounds in CSF

Sleep Disorders Center, Hôpital du Sacré-Coeur (Drs. Montplaisir, Walsh, and Rémillard), the Department of Physiology, Université de Montréal (Dr. de Champlain), and the Department of Psychiatry, McGill University (Drs. Young and Sourkes and K. Missala), Montréal, Québec, Canada.

We measured CSF and serum concentrations of biogenie amines (DA, NE, E, and serotonin), some of their metabolites (HVA, 5-HIAA, and IAA) and tryptophan in 11 narcoleptic, 11 idiopathic hypersomniac, and 11 control subjects. The concentrations of DA and IAA, a metabolite of tryptamine, were significantly decreased in the CSF of both groups of hypersomniacs. Both DA and tryptamine are found in highest concentrations in the striatum, which is probably involved in the physiopathology of hypersomnia.

Address correspondence and reprint requests to Dr. Montplaisir, Sleep Disorders Center, Hôpital du Sacré-Coeur, 5400 boul. Gouin ouest, Montréal, Québec, Canada H4J 1C5.

Supported by grants from the Medical Research Council of Canada. Accepted for publication March 31, 1982.

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