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Benign intracranial hypertensioninduced by deficiency of vitamin A during infancy

Department of Neurology, University of Kentucky and Veterans Administration Medical Centers, and the Sanders-Brown Research Center on Aging, Lexington, KY.

An 8-month-old boy showed clinical signs of sustained elevated intracranial pressure, associated with minimally enlarged ventricles and normal brain parenchyma on CT. The diagnosis of pseudotumor cerebri was confirmed by finding CSF of normal composition at pressures averaging 245 mm H₂O. The infant had undetectable levels of retinol and carotene in his serum, indicating severe deficiency of vitamin A. A causal relationship between intracranial hypertension and the vitamin deficiency was established, when both clinical findings and CSF pressure became normal after 2 months of potential therapy with vitamin A.

Address correspondence and reprint requests to Dr. Kasarskis, Department of Neurology, Albert B. Chandler Medical Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536.

Accepted for publication April 16, 1982.

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