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Lecithin does not affect EEG spectral analysis or P₃₀₀in Alzheimer disease

Section of Neurology (Dr. Hallett), Department of Medicine, Brigham and Women's Hospital and Department of Neurology, Harvard Medical School, the Department of Neurology (Dr. Growdon), New England Medical Center Hospital and Tufts University School of Medicine, Boston, and Wellesley College (Ms. Canter) Wellesley, MA.

We studied 10 patients with Alzheimer disease by measuring EEG compressed spectral analysis and the P₃₀₀ latency and topography before and after 2 weeks of lecithin therapy. There was a significant positive correlation between the degree of dementia measured by the Blessed Dementia Scale and the amount of EEG delta activity. The P₃₀₀ latency was related to the ability to detect the rare tones in the P₃₀₀ paradigm. Lecithin therapy increased mean plasma choline levels but did not affect EEG power or the P₃₀₀ latency or topography.

Address correspondence and reprint requests to Dr. Hallett, Section of Neurology, Brigham and Women's Hospital, Boston, MA 02115.

Accepted for publication March 30, 1982.

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