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Cerebrospinal fluid vasopressin in benign intracranial hypertension

Departments of Neurology (Dr. Sørensen), Medicine P (Dr. Hammer), and Neurosurgery (Dr. Gjerris), State University Hospital, Rigshospitalet, Copenhagen, Denmark.

We measured the concentration of vasopressin in CSF of 10 patients with benign intracranial hypertension (BIH) and 28 patients with lumbar or cervical pain syndromes. Mean CSF vasopressin concentration was significantly higher in patients with benign intracranial hypertension (2.2 ± 0.3 pg per milliliter) than in controls (1.3 ± 0.1 pg per milliliter) (p <0.05). The elevated CSF vasopressin level in BIH could be the result of the increased intracranial pressure, tending to reduce pressure by reducing CSF formation rate or by increasing CSF water reabsorption.

Address correspondence and reprint requests to Dr. Sørensen, Department of Neurology, Rigshospitalet, DK-2100, Copenhagen, Denmark.

Accepted for publication March 30, 1982.