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Liposome-entrapped GABA modifies behavioral and electrographic changes of penicillin-induced epileptic activity

Department of Neurology and the Epilepsy Center of the University of Genova, 16132 Genova, Italy.

We studied Sprague-Dawley rats with spike activity and myoclonus after intraperitoneal injections of penicillin. Twenty minutes after penicillin injection, one group received a random crossover treatment by intraperitoneal GABA (gamma-aminobutyric acid) or liposome-entrapped GABA (LEG) or phosphatidylserine alone. The other group received GABA, LEG, or phosphatidylserine followed 15 minutes later by the injection of penicillin. LEG decreased or prevented the epileptic activity, whereas no significant changes were seen with either GABA or phosphatidylserine given alone. LEG may enhance penetration of GABA across the blood-brain barrier because of the carrier action of the liposomes.

Address correspondence and reprint requests to Prof. C. Loeb, Clinica Neurologica, Università di Genova, Via De Toni, 5, 16132 Genova, Italy.

Part of the data here reported were presented at the Epilepsy International Symposium, Florence, Sept 1979.

This investigation was supported in part by CNR (Gruppo Scienze Neurologiche), Italy.

Accepted for publication April 2, 1982.