HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, K.-M. Articles by Gajdusek, D. C. Search for Related Content PubMed PubMed Citation Articles by Chen, K.-M. Articles by Gajdusek, D. C.

Parkinsonism-dementia in a Filipino migrant

A clinicopathologic case report

Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health (Drs. Garruto and Gajdusek), Bethesda, MD and the NINCDS Research Center (Drs. Chen and Makifuchi), Tamuning, Guam.

A 69-year-old male Filipino migrant developed a clinical syndrome and neuropathologic changes indistinguishable from parkinsonism-dementia (PD). The patient originally migrated from the Ilocos region of the Philippine Islands to Hawaii and then to Guam, where he remained for 26 years before neurologic symptoms began. This is the first case of clinically and neuropathologically verified PD in a non-Chamorro and supports the notion that long-term continuous exposure to the Guamanian environment increases the risk of developing disease.

Address correspondence and reprint requests to Dr. Chen, NINCDS Research Center, P.O. Box 6577, Tamuning, Guam 96911.

Accepted for publication April 19, 1982.

This article has been cited by other articles:

				J. C. Steele and P. L. McGeer The ALS/PDC syndrome of Guam and the cycad hypothesis Neurology, May 20, 2008; 70(21): 1984 - 1990. [Abstract] [Full Text] [PDF]

				D. P. Perl and S. Moalem Aluminum, Alzheimer's Disease and the Geospatial Occurrence of Similar Disorders Reviews in Mineralogy and Geochemistry, January 1, 2006; 64(1): 115 - 134. [Full Text] [PDF]

				H. R. Morris, J. C. Steele, R. Crook, F. Wavrant-De Vrieze, L. Onstead-Cardinale, K. Gwinn-Hardy, N. W. Wood, M. Farrer, A. J. Lees, P. L. McGeer, et al. Genome-Wide Analysis of the Parkinsonism-Dementia Complex of Guam Arch Neurol, December 1, 2004; 61(12): 1889 - 1897. [Abstract] [Full Text] [PDF]