HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mizrahi, E. M. Articles by Tharp, B. R. Search for Related Content PubMed PubMed Citation Articles by Mizrahi, E. M. Articles by Tharp, B. R.

A characteristic EEG pattern in neonatal herpes simplex encephalitis

Department of Neurology, Stanford University Medical Center, Stanford, CA.

EEGs were obtained on six infants with herpes simplex virus (HSV) encephalitis. The first EEG of four of these infants showed a unique multifocal periodic or quasiperiodic pattern; in one of these, a periodic pattern subsequently replaced the quasiperiodic pattern. A fifth infant developed a quasiperiodic pattern on the eighteenth day. All of these infants died or were left with severe encephalopathy. A sixth infant was diagnosed and therapy initiated on day 2. The periodic pattern did not appear in any of this infant's EEGs, and at age 8 months he showed only a moderate motor delay. A periodic EEG in a young infant with partial motor seizures and CSF lymphocytic pleocytosis is virtually diagnostic of HSV encephalitis.

Address correspondence to Dr. Mizrahi, Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, 1200 Moursund Avenue, Houston, TX 77030.

Presented in part at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Canada, April 1981.

Accepted for publication April 19, 1982.

Address reprint requests to Dr. Tharp, Department of Neurology, Room C338, Stanford University Medical Center, Stanford, CA 94305.

This article has been cited by other articles:

				J. S. Hahn and D. M. Olson Etiology of Neonatal Seizures NeoReviews, August 1, 2004; 5(8): e327 - e335. [Full Text] [PDF]

				G Malm and M Forsgren Neonatal herpes simplex virus infections: HSV DNA in cerebrospinal fluid and serum Arch. Dis. Child. Fetal Neonatal Ed., July 1, 1999; 81(1): 24F - 29. [Abstract] [Full Text]

				M. S. Scher and M. Beggarly Clinical Significance of Focal Periodic Discharges in Neonates J Child Neurol, July 1, 1989; 4(3): 175 - 185. [Abstract] [PDF]