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Positron emission tomography in two cases of childhood epileptic encephalopathy (Lennox-Gastaut syndrome)

Cerebrovascular Research Center, Department of Neurology (all authors), Comprehensive Epilepsy Center, Graduate Hospital (Drs. R. C. Gur and Sussman), and the Departments of Psychiatry (Drs Gur and R.E. Gur), Radiology (Drs. Alavi and Goldberg), and Neurosurgery (Dr. O'Connor), University of Pennsylvania, Philadelphia. PA.

Two patients with childhood epileptic encephalopathy were studied by positron emission tomography before and after corpus callosotomy. Preoperatively, both patients showed in the temporal lobe unilateral hypometabolism that is characteristic of interictal epileptic foci. Postoperatively, the first patient had no seizures by the time of scanning, and his temporal lobe metabolism was bilaterally symmetric. Seizure control in the second patient did not improve by the time of scanning, and unilateral temporal hypometabolism persisted. This finding suggests a temporal lobe focus in two patients with Lennox-Gastaut syndrome.

Address correspondence and reprint requests to Dr. Gur, Cerebrovascular Research Center, Department of Neurology, University of Pennsylvania, 429 Johnson Pavillion, Philadelphia, PA 19104.

This work was supported by NIH Grant No. NS19039-09, and NIMH Grant No. 30456, Division of Health and Environmental Research, Department of Energy, and the Spencer Foundation.

Accepted for publication March 2, 1982.

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