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NEUROLOGY 1982;32:1189
© 1982 American Academy of Neurology

Failure of isoniazid therapy in Huntington disease

Donald R. McLean, M.D., F.R.C.P.(C)

Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada.

We carried out a double-blind, videotape-monitored, 3-month crossover study of the effects of isoniazid (900 mg daily) in eight patients with Huntington disease. There was no improvement in the number of adventitious movements.

Address correspondence and reprint requests to Dr. McLean, Department of Medicine (Neurology), University of Alberta, Edmonton. Alberta T6G 2G3, Canada.

Accepted for publication March 8, 1982.






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