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NEUROLOGY 1982;32:1151
© 1982 American Academy of Neurology

Passive transfer studies in Guillain-Barre polyneuropathy

T. E. Feasby, A. F. Hahn and J. J. Gilbert

Department of Clinical Neurological Sciences (Dr. Feasby), University Hospital, London, Ontario, Canada, and the Department of Clinical Neurological Sciences and Department of Pathology (Drs. Hahn and Gilbert), Victoria Hospital, London, Ontario, Canada.

Serum and lymphocytes from patients with acute Guillain-Barre polyneuropathy were injected into rat sciatic nerves. Serum from 13 of 17 patients produced perivenular demyelination, associated with lymphocytic infiltration. The pattern of demyelination differed from that caused by experimental allergic neuritis serum. The level of serum demyelinating activity was greatest early in the disease and then decreased. The demyelinating factor was heat-labile but not complement-dependent. Circulating lymphocytes did not cause demyelination in eight patients.

Address correspondence and reprint requests to Dr. Feasby, Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, P.O. Box 5339, Stn. A, London, Ontario N6A 5A5, Canada.

Supported by the Muscular Dystrophy Association of Canada and the Atkinson Charitable Foundation. A. F. Hahn was supported by a Fellowship from the Medical Research Council of Canada.

Presented in part at the thirty-second annual meeting of the Academy of Neurology. New Orleans, LA, April 1980.

Accepted for publication March 1, 1982.






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