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Lymphocyte studies in a patient with chronic polyradiculoneuropathy

Department of Neurology (Drs. Lin and Rowe), Division of Allergy, Clinical Immunology and Rheumatology (Dr. Abdou), University of Kansas Medical Center, Kansas City, KS, and the Medical University of South Carolina (Dr. Brostoff), Charleston, SC.

We studied immunologic abnormalties in one patient with chronic polyradiculoneuropathy and the effects of immune suppression and plasmapheresis on the clinical course and immune abnormalities. Increased helper T cells and B cells with deficiency of T suppressor cells to B-cell but not to T-cell targets were detected. The patient's blood lymphocytes, but not the controls' lymphocytes, proliferated in vitro on culturing them with P2 antigen in the presence of the patient's CSF. Plasmapheresis combined with corticosteroid and azathioprine reversed the majority of immune abnormalities to normal but did not decrease the patient's lymphocyte-P2 proliferative response; nor did it improve clinical status.

Address correspondence and reprint requests to Dr. Lin, Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66103.

This research was supported in part by USPHS Grant No. AI 15360 and by the Veterans Administration.

Accepted for publication March 10, 1982.

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