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Departments of Neurology (Dr. Bertorini) Medicine (Drs. Palmieri, Chesney, and Pilfer) and Surgery (Dr. Bhattacharya), University of Tennessee Center for the Health Sciences, Baptist Memorial Hospital (Drs. Chesney and Pifer), and St. Jude Children's Research Hospital (Dr. Bertorini and Ms. Baker), Memphis, TN.
Calcium (Ca) and magnesium (Mg) content were determined in muscle of 27 patients with Duchenne muscular dystrophy, 36 with other neuromuscular diseases, and 22 whose muscle biopsy specimens were histochemically normal. Muscle Ca was significantly elevated in all diseases studied but was about 50% higher in Duchenne dystrophy patients (p < 0.0001). Mg was decreased by 44% in Duchenne dystrophy, compared with less striking deficits in other diseases (p < 0.005). In older, nonambulatory Duchenne dystrophy patients, Mg was significantly lower than in younger, ambulatory patients (p < 0.001); muscle Ca was the same in both groups. On the basis of noncollagen nitrogen concentration, muscle Mg depletion could not be attributed solely to reduced muscle mass. These findings strengthen arguments for a role of Ca in the pathogenesis of muscular dystrophy and may implicate Mg depletion as another pathogenetic factor.
Address correspondence and reprint requests to Dr. Bertorini, Department of Neurology, 956 Court, Room 2B03 Memphis, TN 38163.
Supported in part by a grant from the Muscular Dystrophy Association and by Grant No. RR002211 of the USPHS. Dr. Bhattacharya was the recipient of a National Research Service Award in Medicine-Rheumatology from the National Institutes of Health (Grant USPHS No. GR AM 07317) during this investigation.
Portion of the results were presented at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Ontario, April 1981.
Accepted for publication March 30, 1982.
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