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NEUROLOGY 1982;32:63
© 1982 American Academy of Neurology

{gamma}-Aminobutyric acid receptors in normal human brain and Huntington disease

Paul C. Van Ness, Andrew E. Watkins, Mark O. Bergman, W. W. Tourtellotte and Richard W. Olsen

Division of Biomedical Sciences and Department of Biochemistry (Drs. Van Ness, Watkins, Bergman, and Olsen), University of California, Riverside and Neurology Division, Wadsworth Veterans Administration Hospital (Dr. Tourtellotte), Los Angeles, CA.

GABA receptor binding curves were measured in well-washed membrane homogenates from eleven regions of normal human brain and four regions from brains of Huntington disease patients. Computer analysis suggested two populations of receptor sites of different affinity (KD = 10 nM and 240 nM) present in all brain regions but in variable quantity (cerebellar cortex and cerebral cortex > basal ganglia > deeper brain structures). The number of GABA receptor sites in the caudate-putamen region of Huntington brain was less than normal, but the number of sites was increased in Huntington disease substantia nigra. No differences from normal were found in cerebellar cortex or frontal cortex from Huntington disease, and no significant changes in binding affinity were observed for any of the four regions tested under the conditions used.

Address correspondence and reprint requests to Dr. Olsen, Division of Biomedical Sciences, University of California, Riverside, CA 92521.

Supported by funds from the Huntington's Chorea Foundation and Wills Foundation, National Science Foundation Grant No. BNS-77–24414, National Institutes of Health Grants No. NS-12422, RR 09070, AM 07310, and a Research Career Development Award No. NS 00224 to Dr. Olsen.

Accepted for publication June 17, 1981.






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