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NEUROLOGY 1981;31:1184
© 1981 American Academy of Neurology

Neurotransmitter analysis of dermal neurofibromas

Implications for the pathogenesis and treatment of neurofibromatosis

Allan E. Rubenstein, Catherine Mytilineou, Melvin D. Yahr, John Pearson and Menek Goldstein

Department of Neurology (Drs. Rubenstein, Mytilineou, and Yahr), Mount Sinai School of Medicine, City University of New York, and the Departments of Pathology (Dr. Pearson) and Psychiatry (Dr. Goldstein), New York University Medical Center, New York, NY.

We examined 15 dermal neurofibromas from five adults with disseminated neurofibromatosis. All tumors contained axons that reacted for catecholamines and tyrosine hydroxylase on histochemical stains. Assay of tissue homogenates identified norepinephrine as the catecholamine. Assays for dopamine and choline acetyltransferase were negative. Some axonal components of dermal neurofibromas may originate in sympathetic adrenergic neurons. Most dermal neurofibromas do not contain neuronal cell bodies, and some of the axons may maintain functional connections with proximal sympathetic neuronal cell bodies. Sympathetic denervation may therefore affect the growth of these dermal neurofibromas.

Address correspondence and reprint requests to Dr. Rubenstein, Department of Neurology Annenberg 14, Mt. Sinai Hospital, 100 Street and Fifth Avenue, New York, NY 10029.

Supported in part by N.I.H. Grant No. 11631-07 and by a grant from the Enter Scaw Research Foundation.

Accepted for publication December 1, 1980.






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