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Quantitative evaluation of anticonvulsant effects on penicillin-induced spike foci in cats

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.

We evaluated the effects of phenytoin, carbamazepine, phenobarbital, sodium valproate, and ethosuximide on penicillin-induced spike foci. Phenytoin, carbamazepine, and phenobarbital at blood levels within or slightly above the human therapeutic range in humans increased spike frequency, decreased spike duration, and abolished afterdischarges. Ethosuximide and sodium valproate had no statistically significant effect even at blood levels considered toxic in humans. The experimental spike focus and the method of analysis appear useful for: (1) detection of new potentially anticonvulsant drugs, (2) classifying new potentially anticonvulsant drugs according to the type of clinical seizure for which benefit is most likely, and (3) comparing different anticonvulsant drugs.

Address correspondence and reprint requests to Dr. Lueders, Department of Neurology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44106.

Accepted for publication December 12, 1980.