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Sarcoidosis presenting as senile dementia

Departments of Neurology (Drs. Cordingley, Brust, and Heal-ton) and Pathology (Dr. Navarro), Harlem Hospital Center and Columbia University College of Physicians and Surgeons, New York, NY.

Cerebral sarcoidosis was found at autopsy in a 68-year-old woman with progressive dementia. Of 35 previously reported cases of central nervous system sarcoidosis with dementia, only 1 was over 65 years old, and in only 2 was the presenting clinical syndrome that of a degenerative dementia. Other unusual features of the index case include the restriction of the initial cognitive deficit to memory loss and mild anomia, the scarcity of antemortem evidence for systemic sarcoidosis, a positive tuberculin test, and cerebrospinal fluid (CSF) protein concentration as high as 2028 mg per deciliter. Sarcoidosis is a rare but potentially treatable cause of dementia. Consistently normal CSF probably excludes the diagnosis.

Address correspondence and reprint requests to Dr. Brust, Harlem Hospital Center, 506 Lenox Avenue, New York, NY 10037.

Accepted for publication December 19, 1980.

This article has been cited by other articles:

				S. J. Borucki, B. V. Nguyen, C. T. Ladoulis, and R. R. McKendall Cerebrospinal Fluid Immunoglobulin Abnormalities in Neurosarcoidosis Arch Neurol, March 1, 1989; 46(3): 270 - 273. [Abstract] [PDF]

				B. J. Stern, A. Krumholz, C. Johns, P. Scott, and J. Nissim Sarcoidosis and Its Neurological Manifestations Arch Neurol, September 1, 1985; 42(9): 909 - 917. [Abstract] [PDF]