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NEUROLOGY 1981;31:1142
© 1981 American Academy of Neurology

Measles antibody titers in multiple sclerosis patients and HLA-matched and unmatched siblings

Barbara R. Visscher, M.D., Dr, Constance B. Sullivan, M.P.H., Roger Detels, M.D., M.S., David L. Madden, D.V.M., Ph.D., John L. Sever, M.D., Ph.D., Paul I. Terasaki, Ph.D., Min Sik Park, D.V.M. and Jan P. Dudley

School of Public Health (Drs. Visscher and Detels, Ms. Sullivan, and Ms. Dudley), University of California, Los Angeles, CA, the National Institute of Neurological and Communicative Disorders and Stroke (Drs. Madden and Sever), National Institutes of Health, Bethesda, MD, and the Department of Surgery, (Drs. Terasaki and Park), School of Medicine, University of California, Los Angeles, CA.

Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no histocompatibility antigen haplotypes with the case. Significant differences were observed only for measles. Titers were significantly lower in siblings sharing no haplotypes with the case. Within case-sibling pairs, the presence of HLA-A3 and/or B7 affected measles antibody titers more than the presence of MS. These findings suggest that the immune response to measles in these sibships is influenced by the presence of HLA-A3 and/or B7 as well as another familial factor.

Address correspondence and reprint requests to Dr. Visscher, School of Public Health, University of California, Los Angeles, CA 90024.

This work was supported by Grant No. 2R01 NS 10186 from the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health.

Accepted for publication December 24, 1980.




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