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NEUROLOGY 1981;31:944
© 1981 American Academy of Neurology

Canine viruses and multiple sclerosis

M. J. Appel, D.V.M., Ph.D., L. T. Glickman, D.V.M., Ph.D., C. S. Raine, M.D., Ph.D. and W. W. Tourtellotte, M.D., Ph.D.

James A. Baker Institute for Animal Health Dr. Appeli and the Department of Preventive Medicine (Dr. Clickman), New York State College of Veterinary Medicine. Cornell University, Ithaca. NY, the Department of Pathology (Dr. Raine), Albert Einstein College of Medicine of Yeshiva University. Bronx, NY. and the VA Wadsworth Medical Center, National Neurological Research Bank (Dr. Tourtellotte), Los Angeles, CA.

Address correspondence and reprint requests to Dr. Appel, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Serum and cerebrospinal fluid from multiple sclerosis (MS) patients and control subjects were tested and compared for presence and titer of neutralizing antibody against the most common canine viruses. Canine viruses included canine distemper virus (CDV), canine adenovirus 1 (CAV-l), canine parainfluenza virus (CPIV), canine herpesvirus (CHV), canine coronavirus (CCV), and canine parvovirus (CPV). Neutralizing titers against measles virus (MV) and human adenovirus 8 (HA81 were also tested. Significantly elevated (p <0.05) antibody levels in sera from MS patients were found only against MV and CUV, but this depended upon the study population and the method of evaluation. The CDV-neutralizing component in serum could be absorbed on MV-infected cells. Results of this study failed to establish a link between canine viruses and MS.






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