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NEUROLOGY 1981;31:1054
© 1981 American Academy of Neurology

Amantadine and guanidine are ineffective in ALS

Theodore L. Munsat, M.D., Catherine Schmidt Easterday, M.S., RPT, Steven Levy, M.D., Sheldon M. Wolff, M.D. and Robert Hiatt, D. Pharm.

Department of Neurology, School of Medicine, University of California, San Francisco, CA.

Address correspondence and reprint requests to Dr. Munsat, Tufts-New England Medical Center, Department of Neurology, 171 Harrison Avenue, Boston, MA 02111.

Amantadine and guanidine were evaluated in two groups of 10 amyotrophic lateral sclerosis patients each. In a double-blind, crossover design lasting 1 year, neither drug showed therapeutic benefit as compared to placebo.




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 Arch NeurolHome page
H. Mitsumoto, M. R. Hanson, and D. A. Chad
Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials
Arch Neurol, February 1, 1988; 45(2): 189 - 202.
[Abstract] [PDF]


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