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Tetrabenazine and movement disorders

Department of Neurology, University of Southern California, Los Angeles, CA.

Address correspondence and reprint requests to Dr. Aminoff, Room 794-M, Department of Neurology, University of California, San Francisco, CA 94143.

Based on a blind review of videotape recordings, we analyzed the ability of tetrabenazine to suppress abnormal movements. The recordings were done before treatment, after 3 weeks on a stable dose (up to 200 mg daily) of tetrabenazine, and then after 3 weeks on placebo. Among the patients who completed the trial, improvement occurred in 6 of 8 with Huntington disease, 6 of 10 with tardive dyskinesia, and 3 of 8 with dystonic disorders. The drug was usually tolerated well.