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NEUROLOGY 1981;31:1019
© 1981 American Academy of Neurology

Acetylcholine receptor antibodies in infants of mothers with myasthenia gravis

Mitsuhiro Ohta, Ph.D., Fumiyo Matsubara, M.S., Kyozo Hayashi, Ph.D., Kazuwa Nakao, M.D. and Hiroshi Nishitani, M.D.

Departments of Clinical Research (Dr. Ohta and Miss Mat-subara) and Neurology (Dr. Nishitani), Utano National Hospital, the Faculty of Pharmaceutical Sciences (Dr. Hayashi), and the Second Internal Medicine, School of Medicine (Dr. Nakao), Kyoto University, Kyoto, Japan.

Address correspondence and reprint requests to Dr Ohta, Department of Clinical Research. Utano National Hospital, 8 Ondoyama-Cho. Na-rutaki Ukyo-Ku, Kyoto 616, Japan.

Antiacetylcholine receptor (AChR) antibodies were studied in three infants of mothers with generalized myasthenia gravis, using immunoprecipitation and concanavalin A Sepharose assays. Abnormal titers of anti-AChR antibodies were found in all three infants, but only one had symptoms of neonatal myasthenia gravis. The factor inducing transient neonatal myasthenia gravis may depend on the maternal level of anti-AChR antibody.




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