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NEUROLOGY 1981;31:907
© 1981 American Academy of Neurology

Sarcoidosis mimicking glioma

Case report and review of intracranial sarcoid mass lesions

William J. Powers, M.D. and Edward M. Miller, M.D.

Departments of Neurology (Dr. Powers) and Radiology (Dr. Miller), University of California, San Francisco, CA.

Sarcoidosis may rarely cause a discrete intracranial mass lesion. We report a case originally diagnosed as a malignant glioma because of the uneven enhancement and marked white matter edema seen on computerized tomography. Twenty-two reported cases are analyzed, together with our own. Major signs and symptoms are similar to those of other intracranial masses. Coexistent meningeal or hypothalamic involvement is often present, but extracranial sarcoidosis may be absent. The radiologic appearance varies and does not permit distinction from neoplasms or other granulomatous diseases. Treatment with steroids alone seems to be the best choice for initial therapy.

Address correspondence and reprint requests to Dr. Powers, Division of Radiation Sciences, Mallinckrodt Institute of Radiology, 510 South Kingshighway, St. Louis, MO 63110.

Accepted for publication September 29, 1980




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