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Evoked potentials and immunoglobulin abnormalities in multiple sclerosis

Laboratory of Clinical Neurophysiology, the Department of Neurology, and the Laboratory of Clinical Chemistry, Rigshospitalet, University Hospital of Copenhagen, Denmark.

We studied 80 patients with definite, probable, or possible multiple sclerosis, using visual and somatosensory evoked cortical potentials as indicators of manifest or silent plaques. The findings were related to the intracerebral production of immunoglobulin G expressed by the CSF IgG index. Combining the results of evoked potentials and cerebrospinal fluid (CSF) findings, the patients were reclassified. Eight of 18 patients with clinically probable multiple sclerosis were then deemed definite, and 17 of the 42 possible cases were deemed probable. No relation was found between the presumed number of lesions and the rate of intracerebral IgG synthesis.

Address correspondence and reprint requests to Dr. Trojaborg, Laboratory of Clinical Neurophysiology, Kigshospitalet. DK 2100, Blegdarnsvej 9. Copenhagen, Denmark

This investigation was supported by the Danish Medical Research Council.

Accepted for publication September 24, 1980.