HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lueders, H. Articles by Goldensohn, E. S. Search for Related Content PubMed PubMed Citation Articles by Lueders, H. Articles by Goldensohn, E. S.

The independence of closely spaced discrete experimental spike foci

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.

Stable spike foci generated by weak penicillin solutions had a minimal area of distribution of 12.5 mm2. Two foci separated by 4 mm on the same gyrus were consistently dependent and simultaneous. An area of "positive surround" between the two spikes did not prevent dependency. This contradicts the hypothesis that "positive surround prevents spreading of epileptiform discharges. Spike foci separated by 6 mm were almost always independent. Bursts of afterdischarges remained independent if the primary spikes were independent. Postafterdischarge suppression and spreading depression of Lea0 affected independent spike focus selectively. These experiments suggest that cross-talking between cortical columns is limited to columns 1 to 2 mm apart.

Address correspondence and reprint requests to Dr. Lueders, Department of Neurology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44106.

Accepted for publication October 1, 1980.