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Predicting individual phenytoin serum levels of patients Seen in a private Office practice

From the Department of Neurology, Arnett Clinic, Lafayette, IN (Dr Robinson), and the School of Pharmacy, Purdue University, West Lafayette, IN (Mr Warner and Dr Gonzalez).

We evaluated the practicality of predicting phenytoin serum levels in an office practice. Once two phenytoin serum levels were obtained on two different dosage regimens, a table of future doses and predicted serum levels was calculated and plotted on a graph. Subsequent dosage adjustments resulted in serum levels that correlated well with predictions. In 7 of 10 patients, the predicted serum levels were within 2 pg per milliliter of the actual values. To improve compliance, the plot was used as a visual aid in patient education.

Address correspondence and reprint requests to Dr. Robinson, The Arnett Clinic, Inc., P.O. Box 5545, Lafayette, IN 47903.

Accepted for publication August 18, 1980.