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Pseudotumor cerebri in an obese woman with Turner syndrome

From the Departments of Neurology (Dr. Donaldson) and Medicine (Dr. Binstock), University of Connecticut School of Medicine, Farmington, and the Department of Medicine (Dr. Binstock), St. Francis Hospital, Hartford, CT.

Extraovarian estrogen production was studied in an obese young woman with pathologically confirmed mosaic Turner syndrome and pseudotumor cerebri. Diet plus enough dexamethasone to suppress adrenal steroidogenesis promptly lowered cerebrospinal fluid pressure as well as serum content of androstenedione, estrone, and testosterone. Estrone was detected in cerebrospinal fluid before and after but not during dexamethasone treatment. Extraovarian estrogen probably produces the menstrual irregularities of obese young women with pseudotumor cerebri and may be involved in the pathogenesis of that syndrome.

Address correspondence and reprint requests to Dr. Donaldson, Department of Neurology, University of Connecticut Health Center, Farmington, CT 06032.

Accepted for publication August 21, 1980.

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