HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Riggs, J. E. Articles by Lewis, E. D. Search for Related Content PubMed PubMed Citation Articles by Riggs, J. E. Articles by Lewis, E. D.

Acute effects of acetazolamide in hypekalec periodic paraysis

From the Departments of Neurology, Medicine, and Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY.

We studied the effect of acetazolamide on plasma potassium in normals and in two patients with hyperkalemic periodic paralysis. Administration of acetazolamide for 48 hours lowered mean plasma potassium in normals from 4.01 to 3.56 mEq per liter (p <0.001) and in the patients from 4.55 to 4.00 mEq per liter (p <0.001). This kaliopenic effect of acetazolamide may account for its therapeutic action in hyperkalemic periodic paralysis.

Address correspondence and reprint requests to Dr. Riggs, Department of Neurology, 601 Elmwood Avenue, Rochester, NY 14642.

This work was supported in part by grants from the Gannett Foundation and US. Public Health Service Grant No. FLR 00044 from the Division of Research Resources of the National Institutes of Health. Dr. Riggs is a recipient of a Muscular Dystrophy Association, Inc., Clinical Fellowship Grant.

Presented in part at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, May 1980.

Accepted for publication August 21, 1980.

This article has been cited by other articles:

				T D Graves and M G Hanna Neurological channelopathies Postgrad. Med. J., January 1, 2005; 81(951): 20 - 32. [Abstract] [Full Text] [PDF]

				D. B. Allen Defective Aldosterone Synthesis Associated With Hyperkalemic Periodic Paralysis Arch Neurol, March 1, 1993; 50(3): 325 - 328. [Abstract] [PDF]