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NEUROLOGY 1981;31:688
© 1981 American Academy of Neurology

Sleep characteristics in infantile spasms

Richard A. Hrachovy, M.D., James D. Frost, Jr., M.D. and Peter Kellaway, Ph.D.

From the Epilepsy Research Center and the Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, and the Neuro-physiology Service, The Methodist Hospital, Houston, TX.

Sleep staging was performed on 32 patients with infantile spasms. All patients demonstrated significantly less total sleep time and lower percentage of REM time than the expected normal values for age. Seventeen were treated with ACTH or prednisone. There was no increase in total sleep time in those who received hormone therapy, whether or not it was successful. However, the percentage of REM time increased significantly in patients who responded to therapy; this increase occurred concurrently with clinical and electroencephalographic improvement. There was no significant change in REM-sleep values in patients who did not respond.

Address correspondence and reprint requests to Dr. Hrachovy, Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, 1200 Moursund Avenue, Houston, TX 77030.

This study was supported by grant No. NS 11535 and contract No. NS6-2342 from the National Institute of Neurological and Communicative Disorders and Stroke, NIH, USPHS.

Accepted for publication September 8, 1980.




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