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Experimental viral polymyositis

Age dependency and Immune responses to Ross River virus infection in mice

From the Departments of Neurology and Medicine, the Johns Hopkins University School of Medicine, Baltimore, MD.

Ross River virus (RRV) causes an age-dependent myositis in mice. Infected 4-week-old mice develop no clinical signs, but 1-week-old mice develop weakness and myositis. Humoral and cell-mediated immune responses to RRV in the two age groups are comparable, and immunosuppression does not alter age-dependent resistance to clinical disease. Immunosuppression of 1-week-old mice protracts clinical sigris and reduces muscle inflammation but does not alter muscle necrosis or regeneration. These studies suggest that immune responses do not determine age dependency of RRV myositis and that muscle necrosis results from direct viral lysis of muscle fibers.

Address correspondence and reprint requests to Dr. Seay, Johns Hopkins University School of Medicine, Traylor Building, Room 709,720 Rutland Avenue, Baltimore, MD 21205.

This work was supported by Program Project Grant No. NS15721 from the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD. Dr. Seay is a former Research Fellow of the Muscular Dystrophy Association of America and currently is the recipient of a Teacher-Investigator Award (No. 5-K07-Ns-00458-02) from the NINCDS. Dr. Griffin is an investigator of the Howard Hughes Medical Institute.

This paper was presented at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, May 1980.

Accepted for publication September 23, 1980.

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