HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Baruah, J. K. Articles by Munsat, T. L. Search for Related Content PubMed PubMed Citation Articles by Baruah, J. K. Articles by Munsat, T. L.

Retrograde axonal transport of lead in rat sciatic nerve

Neuromuscular Research Laboratories, Department of Neurology, Tuffs-New England Medical Center, Boston, MA.

A wavelike pattern of retrograde axonal transport of lead was demonstrated in rat sciatic nerve after injection of ²⁰³Pb into the triceps surae muscle. The transport rate was about 10 mm per day, and the lead reached the spinal cord by 9 days after injection. The distribution of lead within the spinal cord indicated the possibility of retrograde axonal transport in the upper and lower motor neurons, which might explain how lead enters the central nervous system and could be related to the postulated role of lead in causing amyotrophic lateral sclerosis. Lead may be useful in investigating retrograde transport experimentally.

Address correspondence and reprint requests to Dr. Bradley, Tuffs-New England Medical Center, 171 Harrison Avenue, Boston, MA 02111.

Support by grants from the Muscular Dystrophy Association and the National ALS Foundation. Dr. Baruah was holder of an MDA Clinical Fellowship.

Accepted for publication August 4, 1980