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Tuberculous meningitis

E-rosette-forming T lymphocytes in cerebrospinal fluid

Faculty of Medicine, Ain Shams University, and the U.S. Naval Medical Research Unit No. 3. Cairo, Egypt.

T-lymphocyte subpopulations in cerebrospinal fluid (CSF) and peripheral blood of 20 tuberculous meningitis patients were enumerated by sheep erythrocyte rosette assays. There were fewer active and total T lymphocytes in peripheral blood in patients than in controls. But patient CSF T-lymphocyte subpopulations were significantly higher than their peripheral blood values and no different proportionally from normal peripheral blood values. The results support the concept of immunologic compartmentalization of the neuraxis from the rest of the body.

Address correspondence to Dr. Higashi, Department of Epidemiology, the University of Michigan, 109 Observatory Street, Ann Arbor, MI 48109.

Address reprint requests to Publications Division, U.S. NAMRU-3, FPO, NY 09527.

This work has been supported by the Naval Medical Research and Development Command. National Naval Medical Center, Bethesda, MD, work unit No. 61152N MR00001.01-3025.

Accepted for publication August 5, 1980.