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Lateral and third-ventricular CSF formation after metrizamide CT ventriculography

Departments of Radiology (Dr. Deck) and Neurology (Drs. Dhawan and Rottenberg), Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY.

We calculated the rates of lateral and third-ventricular (LTV) cerebrospinal fluid (CSF) formation in three patients undergoing metrizamide computed tomography (CT) ventriculography with reference to CT estimates of ventricular volume and the time course of LTV metrizamide washout (elimination). Elimination rate constants for metrizamide were derived from measurements of LTV metrizamide concentration on serial postventriculography CT scans, and LTV volumes were estimated by partial volume analysis. CSF formation in the combined lateral ventricles averaged 0.14 ml per minute, and third-ventricular CSF formation averaged 0.014 ml per minute. Thus, the third ventricle accounted for approximately 10% of total LTV CSF production, which accords with the relative weights of choroid plexus tissue in the lateral and third ventricles.

Address correspondence and reprint requests to Dr. Rottenberg, Department of Neurology, Memorial Hospital, 1275 York Avenue, New York, NY 10021.

Supported in part by Grant No. NS 15665 from the National Institutes of Health. Dr. Rottenberg is the recipient of Teacher Investigator Award No. 1 KO7 NS 00286-01 from the National Institute of Neurological and Communicative Disorders and Stroke.

Presented in part at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, April 1980.

Accepted for publication August 5, 1980.