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Interferon responses of leukocytes in multiple sclerosis

Departments of Pathology (Dr. Neighbour), Neurology (Dr. Miller), and Microbiology and Immunology (Drs. Neighbour and Bloom), Albert Einstein College of Medicine, Bronx, NY.

In vitro interferon (IFN) responses of peripheral blood leukocytes to measles virus and to other IFN inducers were determined for multiple sclerosis patients and normal donors. The group mean IFN response to measles virus was significantly lower in patients (15 units) than in normal donors (100 units), and a greater proportion of the patients failed to exhibit a significant IFN response. This defect was not specific for measles virus and was also observed consistently in response to Newcastle disease virus, Poly(I). Poly(C), and concanavalin A. The level of IFN response was not related to the clinical stage of disease.

Address correspondence and reprint requests to Dr. Neighbour, Assistant Professor, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.

This study was supported in part by Grants No. RC 1006-B-2 and RC 1006-C-3 from the National Multiple Sclerosis Society and by Grants No. A1 09807, A1 10702, and NS 15541 from the National Institutes of Health.

Accepted for publication July 29, 1980.

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