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Tomographic mapping of human cerebral metabolism

Normal unstimulated state

Department of Neurology (Dr. Mazziotta) and the Division of Nuclear Medicine (Drs. Phelps and Kuhl and Ms. Miller), UCLA School of Medicine and Laboratory of Nuclear Medicine and Radiation Biology, Los Angeles, CA.

Positron computed tomography (PCT) and F-18 2-fluorodeoxyglucose (FDG) were used to study the living human brain in coronal and transverse sections. Scans taken at 1-cm intervals in both directions clearly delineated the cerebral substructures (e.g., cortical areas, basal ganglia, internal capsule, and cerebellum). A compartmental model was used to calculate local cerebral metabolic rates for glucose from the images. Values agreed well with previous global and local human values and demonstrated metabolic symmetry of the left and right hemispheres at rest. Baseline anatomic maps such as these are a necessary prelude to the study of human brain metabolism in stimulated and pathologic states.

Address correspondence and reprint requests to Dr. Mazziotta, Department of Neurology, Reed Neurologic Institute, UCLA School of Medicine, Los Angeles, CA 90024.

This work was partially supported by DOE contract DE-AM03-76-SF00012, and NIH grants ROI-GM-24839-01 and POI-NS-15654-01

Presented at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, May 2, 1980.

Accepted for publication November 5, 1980.

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