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NEUROLOGY 1981;31:488-491
© 1981 American Academy of Neurology

Homovanillic acid and 5-hydroxyindoleacetic acid in lumbar cerebrospinal fluid in children with afebrile and febrile convulsions

A. Habel, Celia M. Yates, Judith K. McQueen, D. Blackwood and R. A. Elton

From the MRC Brain Metabolism Unit, Edinburgh University Department of Pharmacology, Department of Medical Computing and Statistics (Dr. Elton t Edinburgh University, and the Royal Hospital for Sick Children (Dr. Habel), Edinburgh, Scotland.

Address correspondence and reprint requests to Dr. Yates, MRC Brain Metabolism Unit, Edinburgh University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ, Scotland.

The concentrations of 5-hydroxyindoleacetic acid (5-HIM) and homovanillic acid (HVA) were measured in lumbar cerebrospinal fluid (CSF) from five groups of children: (1) afebrile controls, (2) febrile controls, (3) children with afebrile convulsions, which included children with established idiopathic epilepsy, (4) children with first febrile convulsions, and (5) children with repeated febrile convulsions. There were no significant differences between the metabolite levels in the five diagnostic groups. The CSF concentrations of 5-HIAA and HVA in these children, with a mean age of 2.5 years, were about twice the levels found in adults.

Acknowledgments We thank the pediatricians of the Royal Hospital for Sick Children, Edinburgh, for allowing us to investigate patients in their care, Professor Forfar and Dr. Simpson for continuing support, and Miss Alice Urquhart and Mrs. Lorraine Mackenzie for their technical assistance.

Accepted for publication July 29. 1980






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