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MRC Brain Metabolism Unit, Edinburgh University Department of Pharmacology, Department of Medical Computing and Statistics (Dr. Elton t Edinburgh University, and the Royal Hospital for Sick Children (Dr. Habel), Edinburgh, Scotland.
The concentrations of 5-hydroxyindoleacetic acid (5-HIM) and homovanillic acid (HVA) were measured in lumbar cerebrospinal fluid (CSF) from five groups of children: (1) afebrile controls, (2) febrile controls, (3) children with afebrile convulsions, which included children with established idiopathic epilepsy, (4) children with first febrile convulsions, and (5) children with repeated febrile convulsions. There were no significant differences between the metabolite levels in the five diagnostic groups. The CSF concentrations of 5-HIAA and HVA in these children, with a mean age of 2.5 years, were about twice the levels found in adults.
Address correspondence and reprint requests to Dr. Yates, MRC Brain Metabolism Unit, Edinburgh University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ, Scotland.
Accepted for publication July 29. 1980
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