HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Seybold, M. E. Articles by Lindstrom, J. M. Search for Related Content PubMed PubMed Citation Articles by Seybold, M. E. Articles by Lindstrom, J. M.

Myasthenia gravis in infancy

San Diego VA Medical Center, San Diego, CA, and the Departments of Neurosciences and Surgery, University of California, San Diego (Dr. Seybold) and the Salk Institute for Biological Studies (Dr. Lindstrom), San Diego, CA.

Symptoms of myasthenia gravis in infancy may occur from passive transfer of maternal disease, acquired autoimmune disease, or nonautoimmune hereditary disease. Of nine patients with infantile-onset myasthenia who were not born to mothers with the disease, two had detectable antibody to acetylcholine receptor. Patients with or without antibodies were clinically indistinguishable, except for the occurrence of similar disease in siblings of patients without antibody. Differentiation of autoimmune and hereditary myasthenia in infancy is necessary for appropriate therapeutic measures and genetic counseling. Antibody determinations provide a useful aid in this differentiation.

Address correspondence and reprint requests to Dr. Seybold, (V-1271, San Diego VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161.

This investigation was supported in part by the Veterans Administration.

Accepted for publication July 22, 1980

This article has been cited by other articles:

				A. K. Afifi and W. E. Bell Tests for Juvenile Myasthenia Gravis: Comparative Diagnostic Yield and Prediction of Outcome J Child Neurol, October 1, 1993; 8(4): 403 - 411. [Abstract] [PDF]

				O. Papazian Topical Review Article: Transient Neonatal Myasthenia Gravis J Child Neurol, April 1, 1992; 7(2): 135 - 141. [Abstract] [PDF]

				J. M. Dooley, H. Writer, E. J. Gibson, and J. MacSween The Clinical Spectrum: A Practical Approach to Diagnosis and Treatment Clinical Pediatrics, December 1, 1988; 27(12): 575 - 578. [PDF]