HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Longstreth, W. T. Articles by Sumi, S. M. Search for Related Content PubMed PubMed Citation Articles by Longstreth, W. T., Jr. Articles by Sumi, S. M.

Cerebrospinal fluid and Serum creatine kinase BB activity after out-of-hospital cardiac arrest

Division of Neurology (Drs. Longstreth and Sumi) Department of Medicine, Harborview Medical Center, and the Department of Laboratory Medicine (Ms. Clayson). University of Washington School of Medicine, Seattle, WA.

In patients resuscitated from out-of-hospital cardiac arrest, neurologic outcome was compared with creatine kinase isoen-zyme BB activity (CKBB) in cerebrospinal fluid (CSF) in 20 patients and in serum in 52 patients. CSF CKBB was 2 units Der liter or less in patients with complete neurologic recovery but was significantly elevated in patients without neurologic recovery (mean, 55 units per liter) or with incomplete neurologic recovery (mean, 7 units per liter). Serum CKBB was detected more than 6 hours after cardiac arrest in only 4% of patients with complete neurologic recovery but in all patients without neurologic recovery. These results demonstrate a relationship between CSF and serum CKBB and neurologic outcome after cardiac arrest.

Address correspondence and reprint requests to Dr. Sumi, Division of Neurology, Harborview Medical Center, 325 Ninth Avenue. Seattle, WA 98104.

Accepted for publication June 25. 1980

This article has been cited by other articles:

				R. W. Neumar, J. P. Nolan, C. Adrie, M. Aibiki, R. A. Berg, B. W. Bottiger, C. Callaway, R. S.B. Clark, R. G. Geocadin, E. C. Jauch, et al. Post-Cardiac Arrest Syndrome: Epidemiology, Pathophysiology, Treatment, and Prognostication A Consensus Statement From the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council Circulation, December 2, 2008; 118(23): 2452 - 2483. [Full Text] [PDF]

				E.F.M. Wijdicks, A. Hijdra, G. B. Young, C. L. Bassetti, and S. Wiebe Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, July 25, 2006; 67(2): 203 - 210. [Abstract] [Full Text] [PDF]

				W. M. Coplin, W. T. Longstreth Jr, A. M. Lam, W. L. Chandler, T. S. Mayberg, J. S. Fine, and H. R. Winn Cerebrospinal Fluid Creatine Kinase-BB Isoenzyme Activity and Outcome After Subarachnoid Hemorrhage Arch Neurol, November 1, 1999; 56(11): 1348 - 1352. [Abstract] [Full Text] [PDF]

				R. M. Smith and T. S. Neuman Elevation of Serum Creatine Kinase in Divers with Arterial Gas Embolization N. Engl. J. Med., January 6, 1994; 330(1): 19 - 24. [Abstract] [Full Text]