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Axonal lesions in acute experimental demyelination

A sequential teased nerve fiber study

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA

The relationship between axonal degeneration and primary demyelination was studied in isolated rat sciatic nerve fibers previously exposed to antiserum from rabbits with either experimental allergic neuritis or experimental allergic encephalomyelitis, or immunized with antigalactocerebroside antiserum. Continuous demyelination over one to eight or more internodes was seen in association with phagocytic cells or, later, with increased numbers of Schwann cells. Paranodal demyelination was prominent proximal and distal to the zone of continuous demyelination. Axonal degeneration affected 5 to 15% of myelinated fibers exposed to antiserum and was not related to the length of demyelination just proximal to the axonal changes. At times, there were seven or eight consecutive demyelinated internodes with no distal axonal degeneration; in contrast, one demyelinated internode was often associated with axonal degeneration beginning just distally. The inflammatory reaction could account for axonal degeneration in antiserum-mediated demyelination.

Address correspondence and reprint requests to Dr. Asbury, Professor and Chairman, Department of Neurology G1, University of Pennsylvania, Philadelphia, PA 19104.

This study was supported by Grants Nos. NS11307 and "8075 from the National Institutes of Health, by Grant No. 8948 from the National Multiple Sclerosis Society, by the Kroc Foundation, and by Conseil Scientifique, University of Paris XI.

Accepted for publication June 16, 1980.

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