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Naloxone and focal epilepsy

A study with depth electrodes

From the Centre d'etude de L'epilepsie (Drs. Montplaisir, Saint-Hilaire, and Bouvier), H opital Notre-Dame, and the Centred' etude du sommeil (Drs. Montplaisir, Walsh, and Laverdi ere),H opital du Sacr'Coeur, Montreal, Quebec, Canada.

Intravenous injections of naloxone (0.8 to 2.4 mg) were given to patients with focal epilepsy who had had electrodes implanted in cortical and subcortical structures. There were no changes in interictal spike activity, responses to electrical stimulation, or frequency of spontaneous seizures. These data do not support the hypothesis that opiate peptides are involved in human focal epilepsy.

Address correspondence and reprint requests to Dr. Montplaisir, Centre d etude du sommeil, Hopital du Sacr'e-Coeur, Montreal, Montreal, Quebec H4J 1C5, Canada.

This research was supported by a grant from le Conseil de Recherches Medicales du Canada and a grant from le Fonds de Developpement de la Recherche, Universite de Montreal.

Accepted for publication June 10, 1980.