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NEUROLOGY 1981;31:1552
© 1981 American Academy of Neurology

Alzheimer disease

Lack of effect of lecithin treatment for 3 months

Pierre Etienne, M.D., Dolly Dastoor, M.A., Serge Gauthier, M.D., Robin Ludwick, M.A. and Brian Collier, Ph.D.

Douglas Hospital Research Center (Dr Etienne, Ms Dastoor, and Ms Ludwick), the Montreal Neurological Institute (Dr Gauthier), and the Department of Pharmacology and Therapeutics (Dr Collier), McGill University Montreal, Quebec, Canada

Address correspondence and reprint requests to Dr Etienne Douglas Hospital Research Center, 6875 Boulevard Lasalle, Verdun, Quebec, Canada, H4H 1R3

Eleven outpatients with Alzheimer disease of moderate severity completed a double-blind placebo-controlled crossover trial of lecithin. Each patient received 10 gm three times daily of a placebo for 3 months. Plasma choline levels rose threefold and remained at that level throughout the lecithin administration period. A significant difference between mean baseline scores and treatment scores was found on tests of new learning ability, indicating a practice effect in there tests. However, there were no differences between mean placebo and lecithin scores on any of the psychological test measures.




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