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From the Department of Neurology (Drs. Kelly and Dyck), the Division of Hematology and Internal Medicine (Dr. Kyle), the Division of Endocrinology, Metabolism, and Internal Medicine (Dr. Miles) and the Section of Medica1 Research Statistics (Dr. O'Brien), Mayo Clinic and Mayo Foundation, Rochester, MN.
The records of 20 patients with typical or sclerotic (sclerotic or mixed sclerotic and lytic) multiple myeloma and peripheral neuropathy who were seen during a 13-year period were analyzed to determine the natural history of the neuropathy. In the 10 patients with typical multiple myeloma, the clinical pattern was heterogeneous. Chemotherapy for multiple myeloma did not affect the neuropathy. The 10 patients who had sclerotic myeloma presented in a relatively homogeneous manner, with a predominantly motor neuropathy. Tumoricidal radiation therapy to localized plasmacytomas resulted in pronounced improvement in the neuropathy of two patients, mild improvement in three, and mild improvement in the endocrine abnormalities of one patient.
Address correspondence and reprint requests to Dr. Kelly, Mayo Clinic, Rochester, MN 55901
This investigation was supported in part by Peripheral Neuropathy Clinical Center Grant No. NS-14304 and Grant No. CA-16835 from the NIH, MDA Center Grant No. 12, and by the Mayo, Borchard, Upton, and Gallagher Funds.
Accepted for publication March 26, 1980
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