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Myelinotoxic activity on tadpole optic nerve of IgG isolated from CSF and serum of patients with multiple sclerosis

From the Departments of Ophthalmology (Dr. Stendahl-Brodin), and Neurology (Dr. Link), University Hospital, Linkoping, and the Department of Pathology (Dr. Kristensson), Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden.

IgG from individual cerebrospinal fluid (CSF) and sera from patients with multiple sclerosis and from controls was isolated by protein A-Sepharose column chromatography and tested in the tadpole optic nerve system for myelinotoxic activity. Oligoclonal IgG was present in all multiple sclerosis CSF specimens used. All IgG preparations yielded optic nerve myelin lesions, indicating that IgG has myelinotoxic activity. Significantly higher numbers of myelin lesions were obtained with IgG prepared from multiple sclerosis CSF compared to control CSF IgG.

Address correspondence and reprint requests to Dr. Link, Department of Neurology, University Hospital, S-581 85 Linkoping, Sweden.

This work was supported by grants from the Swedish Medical Research Council (Projects Nos. 3381 and 4480).

Accepted for publication February 7, 1980.