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From the Neuropathology Unit, Departments of Neurology and Pathology, University of Ghent, Belgium.
We studied the clinicopathologic findings in four hypertensive patients with multiple leukomalacia, demyelinated lesions, and lacunar state. Only one patient had clinical evidence of dementia. The periventricular watershed infarcts were attributed to transient episodes of cardiac failure in brains with a compromised circulation in the territory of the deep perforating branches. These observations suggest that Binswanger encephalopathy does not differ from multi-infarct dementia.
Address correspondence and reprint requests to Neuropathology Unit, Akademisch Ziekenhuis, De Pintelaan 135, B-9000 Ghent, Belgium.
Accepted for publication November 30, 1979.
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