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From the Neurology Service and the Charles S. Kubik Laboratory of Neuropathology, Massachusetts General Hospital, Boston, MA.
In the light of advances in computerized tomography (CT), we have retrospectively evaluated the assumptions that underlie the radiation therapy of glioblastoma: (1) No neuroradiologic technique provides an accurate delineation of tumor bulk and location, (2) glioblastoma is commonly multicentric, and (3) a major source of therapeutic failure is recurrence beyond radiotherapy fields.
Because most patients show recurrence within or in close proximity to the original site, current radiation doses would appear to be inadequate for therapy of the primary tumor. CT scan accuracy may permit smaller-field and higher-dose irradiation therapy for glioblastoma.
Address correspondence and reprint requests to Dr. Hochberg, Neurology Service, Massachusetts General Hospital, Boston, MA 02114.
Accepted for publication December 11, 1979.
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