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Antibodies to acetylcholine receptor in patients with thymoma but without myasthenia gravis

Department of Biochemistry, University of Geneva, Switzerland (Drs. Cuénoud and Fulpius); the Department of Autoimmune Diseases, Central Laboratory. Netherlands Red Cross Blood Transfusion Service, and the Laboratory of Clinical and Experimental Immunology, University of Amsterdam, The Netherlands (Dr. Feltkamp); and the Department of Neurology, University Hospital, Groningen, The Netherlands (Dr. Oosterhuis).

Antibodies to acetylcholine receptor were found in 3 of 11 patients with a thymoma removed by operation but without myasthenia gravis. Because myasthenia gravis may appear after removal of the thymoma, detection of antiacetylcholine receptor antibodies may have predictive value.

Address correspondence and reprint requests to Dr. Fulpius, Département de Biochimie, Université de Genève, CH 1211 Genève 4, Switzerland.

Accepted for publication July 3, 1979.

This work was supported by grant No. 3.157.77 from the Swiss National Fund for Scientific Research and by a grant from the Sandoz Foundation.

Presented in part at the International Conference on Plasmapheresis and the Immunobiology of Myasthenia Gravis, San Francisco, CA, June 1978.

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