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Departments of Psychology and Social Sciences (Neuropsychology Section), Neurological Sciences, and Diagnostic Radiology, Rush-Presbyterian-St. Luke's Medical Center and Rush University, Chicago.
Seventy-eight hospital patients, 50 years of age or older, were selected for suspected changes in mentation and for the absence of focal or other organic brain disease. They were studied in relation to education, age, cerebral atrophy (by computerized tomography), electroencephalographic (EEG) slowing, and performance in several neuropsychologic tests. Adequate test-retest reliability of the cognitive measures and interjudge reliability of the cerebral atrophy and EEG measures were demonstrated. Stepwise multiple regression analyses suggested the following: (1) EEG slowing is the strongest and most general pathologic influence on cognition in elderly persons without overt brain disease. (2) Cerebral atrophy independently affects primarily the verbal recall of recent and remote information. (3) Age independently affects primarily recent memory for both verbal and nonverbal material. (4) Formal education is a powerful influence that must be accounted for in all studies of the effects of age on cognition.
Dr. Kaszniak's address is Department of Psychology and Social Sciences, Rush-Presbyterian-St. Luke's Medical Center, 1753 West Congress Parkway, Chicago, 1L 60612.
Presented at the sixth annual meeting of the International Neuropsychological Society, Minneapolis, February 1978.
This work was supported in part by USPHS Grant No. AG00905.
Accepted for publication February 20, 1979.
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